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Our Clinical Research

Langford Vets is passionately committed to excellence in animal health and being at the forefront of clinical care including advancing knowledge through research. Langford Vets undertakes world leading clinical research that is internationally disseminated, not only improving animal health and welfare locally, but also throughout the world.

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Clinical Research at Langford Vets

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Bristol Vet School at 75 Research Celebration

Langford Vets joined BVS for a BVS@75yrs research celebration day. Research including clinical research from the past, present and future was showcased. Georgina Knight presented a poster about MALDI-TOF and its potential contribution to diagnostic and research work.

Latest news & stories  Our Clinical Research Updates

Actively Recruiting Studies

Mitral Valve Clinic

The Mitral Valve Clinic at Langford Vets is run by Dr Melanie Hezzell, a specialist veterinary cardiologist with a PhD in the epidemiology of canine myxomatous mitral valve disease. The Mitral Valve Clinic is a prospective, longitudinal cohort study of canine myxomatous mitral valve disease. Participating dogs typically attend the clinic every 6 months. At each visit they undergo comprehensive monitoring of their disease, including a full clinical examination, blood pressure measurement, an ECG, an ultrasound of their heart and blood and urine tests. The clinic aims to collect information about how the disease develops and progresses over time, and the factors that determine why some dogs have mild, non-progressive disease while others have a severe, rapidly progressive phenotype.

The clinic aims to benefit both current patients, by providing heavily subsidised expert monitoring for dogs with mitral valve disease and future patients, by investigating how and why this disease develops and progresses. Our goal is to develop new treatments and therapies that will improve the dogs’ lives. The clinic also nurtures the next generation of veterinary clinical researchers by providing opportunities for veterinary surgeons to undertake Masters by Research and PhD studentships.

For more information, please contact Melanie Hezzell: mh16511@bristol.ac.uk or Langford Vets Small Animal Hospital reception 0117 394 0513.

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Langford Vets Clinical Research Fund

Langford Vets has a clinical research fund to support research projects undertaken by Langford Vets employees and University of Bristol employees who work within Langford Vets clinics.

Here are the latest projects that have been funded:

Urinary EHD3 in cats...

Urinary EHD3 in cats with CKD

Principal investigator: Josh Kennils

Chronic kidney disease (CKD) is a significant cause of morbidity and mortality in cats. It is characterised by progressive loss of filtration function evaluated in patients by measuring surrogate markers of glomerular filtration rate such as serum creatinine concentration.

Eps homology domain protein 3 (EHD3) is localised to the glomerular endothelial cells (GEnC) in the kidney. We have previously shown that its loss is associated with loss of renal filtration function in people and mouse models of diabetes, the mechanism of which is by loss of GEnC fenestrations (pores through which fluids and small solutes filter from blood through the glomerular filtration barrier). We have also shown that EHD3 is a key regulator of these structures.

Given the critical role of EHD3 in regulating GEnC fenestrations and therefore renal filtration function, it is highly plausible that its loss may play a role in CKD. As EHD3 is localised to the GEnCs in the kidney, its presence in urine provides a specific marker of damage to these cells. A urinary biomarker of damage to a particular kidney cell type in CKD is highly desirable in cats. EHD3 may provide a much-needed therapeutic target which slows declining renal filtration function.

Validation of 3D...

Validation of 3D merged fast field echo MRI sequences (FRACTURE, M-FFE) for generation of 3D printed vertebral drill guides.

Principal Investigator: Richard Lawn

Surgical treatment of complex spinal malformations and instabilities with the aid of 3D printed customised surgical implants and drill guides has gained increased popularity in veterinary medicine over the last years and has been recently implemented at LVS. The processes involved in the manufacturing of 3D printed implants/drill guides is complex and requires, among other steps, acquisition of both MRI and CT studies from the same patient, with generation of anatomically accurate vertebral models relying mainly on the latter. However, the need for both advanced images, has a negative impact on hospital workflow, by reducing capacity for scanning patients, on patient’s safety due to radiation exposure, increasing anaesthesia length, and increased costs for the Owners. We have recently identified the suitability of “Fast field echo resembling a CT using restricted echo-spacing” (FRACTURE) and other 3D merged fast field echo (M-FFE) MRI sequences, for direct generation of 3D printed anatomical models of canine spines. Validation of this technique to generate vertebral drill guides too, may remove the need to perform post- MRI CT studies. Aim of the study is to verify accuracy of intrapedicular screw placement using vertebral drill guides generated with MRI based technique compared to those produced with established CT based techniques. Information from this study may help to simplify and reduce the cost of surgical planning in neurosurgical procedures where both an MRI and CT are currently required.

The impact of Simini antiseptic...

The impact of Simini antiseptic lavage solution on Pseudomonas biofilm on three different orthopaedic implant materials.

Principal Investigator: Daniel Lomas

Simini is a lavage solution that is used intra-operatively to reduce biofilm on orthopaedic implants in the presence of infection or in surgeries with a higher expected infection rate e.g revision surgery. The solution does not contain antibiotics and is a combination of active ingredients. It therefore aims to reduce the use of antibiotics in orthopaedic surgery. In addition, biofilms are inherently resistant to penetration by antibiotics. Simini has been theorised to have a synergistic effect with antibiotic therapy by weakening or disrupting the bacterial biofilm.

 The effectiveness of this solution has not been demonstrated on pseudomonas biofilms which is commonly isolated bacteria from veterinary orthopaedic infections and tends to form implant biofilms easily.  In addition, the effectiveness on 316L stainless steel, which is the most used material in veterinary orthopaedic implants, has not been investigated.

Recent Publications

Choose one of the business areas below to see recent publications from each team:

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