British Shorthair Autoimmune Lymphoproliferative Syndrome (ALPS) is a non-neoplastic, lymphoproliferative disease characterised by an accumulation of immune cells in the lymph nodes and spleen, which results in these tissues becoming dramatically enlarged. The disease presents at an early age (6-8 weeks) and progresses rapidly (2-3 weeks) when the kittens show abdominal distension, anaemia, lethargy and weight loss. Affected kittens either die or are euthanised within a short time (4 weeks) of presentation.
The Molecular Diagnostic Unit at Langford Vets has developed a PCR-based pyrosequencing assay to quickly and accurately identify the FASL mutation that causes BSH ALPS. This assay will allow breeders to identify British Shorthair cats carrying the mutation, particularly amongst those imported from Australia or New Zealand, and therefore prevent carrier to carrier matings, which could result in ALPS affected kittens being born.
The Cat Genetics team will be attending the GCCF Supreme Cat Show this Staurday (28th October) and will be on hand to answer any questions that you may have about this new test and any of the other genetics test that we offer.
For more information or to request the test, please visit: www.langfordvets.co.uk/british-shorthair-autoimmune-lymphoproliferative-syndrome-alps
*The test costs £29.50 + VAT. For members of breed clubs registered with us, the cost is only £23.60 + VAT.