Molecular Diagnostic Unit Publications

The Molecular Diagnostic Unit is at the forefront of infectious and genetic disease research and has been involved in the publication of over 110 scientific papers and articles. Please see below for a selection of our papers.

Infectious Diseases

Canine Haemoplasma

Hetzel N.J., Barker E.N., Helps C.R., Tasker S., Arteaga A., Barrs V.R. and Beatty J. (2012). Prevalence of canine haemotropic mycoplasma infections in Sydney, Australia. Vet Rec. 171, 126-127.

Barker E.N., Langton D.A., Helps C.R., Brown G., Malik R., Shaw, S. and Tasker S. (2012). Haemoparasites of free-roaming dogs associated with several remote Aboriginal communities in Australia. BMC Vet Res. 8, 55.

Tennant K.V., Barker E.N., Polizopoulou Z., Helps C.R., and Tasker S. (2011). Real-time quantitative PCR detection of haemoplasmas in healthy and unhealthy dogs from Central Macedonia, Greece. J. Small Animal Practice. 52, 645-649.

Barker E.N., Tasker S., Day M.J., Warman S.M., Woolley K., Birtles R., Georges K., Ezeokoli C.D., Newaj-Fyzul A., Campbell M., Sparagano O., Cleaveland S. and Helps C.R.(2010). Development and use of real-time PCR to detect and quantify Mycoplasma haemocanis and 'Candidatus Mycoplasma haematoparvum' in dogs. Vet. Micro. 140, 167-170.

Roura X., Peters I.R., Altet L., Tabar M-D., Barker E.N., Planellas M., Helps C.R., Francino O., Shaw S.E. and Tasker S. (2010). Prevalence of hemotropic mycoplasmas in healthy and unhealthy cats and dogs in Spain. Journal of Veterinary Diagnostic Investigation. 22, 270-274.

Hulme-Moir K.L., Barker E.N., Stonelake A., Helps C.R. and Tasker S. (2010). Use of real-time quantitative polymerase chain reaction to monitor antibiotic therapy in a dog with naturally acquired Mycoplasma haemocanis infection. Journal of Veterinary Diagnostic Investigation. 22, 582-587.

Warman S.M., Helps C.R., Barker E.N., Day S., Sturgess K., Day M.J. and Tasker S. (2010). Haemoplasma infection is not a common cause of canine immune-mediated haemolytic anaemia in the UK. J. Small Animal Practice. 51, 534-539.

Chlamydia felis (formerly Chlamydophila felis)

Schulz C., Hartmann K., Mueller R.S., Helps C.R. and Schulz B.S. (2015). Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. Journal of Feline Medicine and Surgery. 17, 1012-1019.

Segarra S., Papasouliotis K. and Helps C.R. (2011). The in vitro effects of proxymetacaine, fluorescein and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Veterinary Ophthalmology. 14, 5-8.

Harley R., Cantanese B. and Helps C.R. (2010). Polymorphic membrane proteins 1 and 7 from Chlamydophila felis are significant immunodominant proteins. Veterinary Microbiology. 144, 415-421.

Harley R., Day S., Di Rocco C. and Helps C. (2010). The Chlamydophila felis plasmid is highly conserved. Vet. Microbiol. 146, 172-174.

Hartmann A., Helps C.R., Lappin M., Werckenthin C. and Hartmann K. (2008). Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections. Journal of Veterinary Internal Medicine. 22, 44-52.

Harley R., Herring A., Egan K., Howard P., Gruffydd-Jones T.J., Azuma Y., Shira M. and Helps C.R. (2007). Molecular characterisation of 12 Chlamydophila felis polymorphic membrane protein genes. Veterinary Microbiology. 124, 230-238.

Dean R., Harley R., Helps C., Caney S. and Gruffydd-Jones T. (2005). Response of Chlamydophila felis infection to doxycycline treatment using quantitative real-time PCR. Journal of Clinical Microbiology. 43, 1858-1864.

Helps C.R., Lait P., Damhuis A., Björnehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G., Fontbonne A., Grazia Pennisi M., Gruffydd-Jones T., Gunn-Moore D., Hartmann K., Lutz H., Malandain E., Möstl K., Stengel C., Harbour D.A. and Graat E.A.M. (2005). Factors associated with upper respiratory tract disease caused by FHV, FCV, C. felis and B. bronchiseptica in cats - experience from 218 European catteries. The Veterinary Record. 156, 669-673.

Helps C.R., Reeves N. A., Egan K., Howard P. and Harbour D.A. (2003). Detection of Chlamydophila felis and feline herpesvirus by multiplex real-time PCR. Journal of Clinical Microbiology. 41, 2734-2736.

Helps C., Reeves N., Tasker S. and Harbour D. (2001). Use of real-time quantitative PCR to detect Chlamydophila felis infection. Journal of Clinical Microbiology. 39, 2675-2676.

Feline Bordetella bronchiseptica

Helps C.R., Lait P., Damhuis A., Björnehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G., Fontbonne A., Grazia Pennisi M., Gruffydd-Jones T., Gunn-Moore D., Hartmann K., Lutz H., Malandain E., Möstl K., Stengel C., Harbour D.A. and Graat E.A.M. (2005). Factors associated with upper respiratory tract disease caused by FHV, FCV, C. felis and B. bronchiseptica in cats - experience from 218 European catteries. The Veterinary Record. 156, 669-673.

Feline Calicivirus

Schulz C., Hartmann K., Mueller R.S., Helps C.R. and Schulz B.S. (2015). Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. Journal of Feline Medicine and Surgery. 17, 1012-1019.

Friedl Y., Schulz B., Knebl A., Helps C.R., Truyen U. and Hartmann K. (2014). Efficacy of passively transferred antibodies in cats with acute viral upper respiratory tract infection. Veterinary Journal. 201, 316-321.

Ballin A.C., Schulz B., Helps C.R., Sauter-Louis C., Mueller R.S. and Hartmann K. (2014). Limited efficacy of topical recombinant feline interferon-omega for treatment of cats with acute upper respiratory viral disease. The Veterinary Journal. 202, 466-470.

Helps C.R., Lait P., Damhuis A., Björnehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G., Fontbonne A., Grazia Pennisi M., Gruffydd-Jones T., Gunn-Moore D., Hartmann K., Lutz H., Malandain E., Möstl K., Stengel C., Harbour D.A. and Graat E.A.M. (2005). Factors associated with upper respiratory tract disease caused by FHV, FCV, C. felis and B. bronchiseptica in cats - experience from 218 European catteries. The Veterinary Record. 156, 669-673.

Helps C.R. and Harbour D.A. (2003). Detection of nucleotide polymorphisms in feline calicivirus isolates by reverse transcription PCR and a fluorescence resonance energy transfer probe. Journal of Virological Methods. 109, 261-263.

Helps C. R., Lait P., Tasker S. and Harbour D. A. (2002). Melt curve analysis of feline calicivirus isolates detected by real-time reverse transcription PCR. Journal of Virological Methods. 106, 241-244.

Feline Coronavirus

Lewis C.S., Porter E., Matthews D., Kipar A., Tasker S., Helps C.R. and Siddell S.G. (2015). Genotyping coronaviruses associated with feline infectious peritonitis. Journal of General Virology. 96, 1358-1368.

Longstaff L., Porter E., Crossley V., Hayhow S., Helps C.R. and Tasker S. (2015). Feline coronavirus quantitative reverse-transcriptase polymerase chain reaction on effusion samples in cats with and without feline infectious peritonitis. Journal of Feline Medicine and Surgery. In press.

Tekelioglu B.K., Berriatua E., Turan N., Helps C.R., Kocak M. and Yilmaz H. (2015). A retrospective clinical and epidemiological study on feline coronavirus (FCoV) in cats in Istanbul, Turkey. Prev. Vet. Med. 119, 41-47.

Porter E., Tasker S., Day M.J., Harley R., Kipar A., Siddell S.G. and Helps C.R. (2014). Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis. Veterinary Research. 45, 49.

Barker E., Tasker S., Gruffydd-Jones T.J., Tulpin C.K., Burton K., Porter E., Day M.J., Harley R., Fews D., Helps C.R.,and Siddell S.G. (2013). Phylogenetic analysis of feline coronavirus strains in an epizootic outbreak of feline infectious peritonitis. Journal of Veterinary Internal Medicine. 27, 445-450.

Feline Haemoplasma

Weingart C, Tasker S & Kohn B. (2016). Infection with haemoplasma species in 22 cats with anaemia. Journal of Feline Medicine and Surgery 18 129-136.

Aquino L.C., Kamani J., Haruna A.M., Hicks C.A., Helps C.R. and Tasker S. (2016). Analysis of risk factors and prevalence of haemoplasma infection in dogs. Veterinary Parasitology. 221, 111-117.

Carver S, Beatty JA, Troyer RM, Harris RL, Stutzman-Rodriguez K, Barrs VR, Chan CC, Tasker S, Lappin MR & VandeWoude S. (2015). Closing the Gap on Causal Processes of Infection Risk from Cross-Sectional Data: Structural Equation Models to Understand Infection and Coinfection. Parasites and Vectors 8 658.

Hicks C., Willi B., Riond B., Novacco M., Meli M, Stokes C., Helps C., Hofmann-Lehmann R. and Tasker S. (2015). Protective immunity against infection with Mycoplasma haemofelis. Clinical and Vaccine Immunology. 22, 108-118.

Aquino L., Hicks C., Scalon M., da M. Lima M., dos S. Lemos M., Paludo G., Helps C. and Tasker S. (2014). Prevalence and phylogenetic analysis of haemoplasmas from cats infected with multiple species. Journal of Microbiological Methods. 107C, 189-196.

Ghazisaeedi F, Atyabi N, ZahraiSalehi T, Gentilini F, AshrafiTamai I, Akbarein H & Tasker S. (2014). A molecular study of haemotropic mycoplasmas (haemoplasmas) in cats in Iran. Veterinary Clinical Pathology 43: 381-386.

Hicks C.A., Barker E.N., Brady C., Stokes C.R., Helps C.R. and Tasker S. (2014). Non-ribosomal phylogenetic exploration of Mollicute species: New insights into haemoplasma taxonomy. Infection, Genetics and Evolution. 23, 99-105.

Jenkins KS, Dittmer KE, Marshall JC & Tasker S. (2013). Prevalence and risk factor analysis of feline haemoplasma infection in New Zealand domestic cats using a real-time PCR assay. Journal of Feline Medicine and Surgery 15: 1063-1069.

Barker E.N., Darby A., Helps C.R., Peters I.R., Hughes M., Radford A., Novacco M., Boretti F., Hofmann-Lehmann R., and Tasker S. (2012). Genome Sequence for “Candidatus Mycoplasma haemominutum", a low-pathogenicity hemoplasma species. Journal of Bacteriology. 194, 905-906.

Pitorri F, Dell’Orco M, Carmichael N, Barker EN, Hollywood M & Tasker S. (2012). Use of real-time quantitative PCR to document successful treatment of Mycoplasma haemocanis infection with doxycycline in a dog. Veterinary Clinical Pathology 41: 493-496.

Georges K, Ezeokoli C, Auguste T, Seepersad N, Pottinger A, Sparagano O & Tasker S. (2012). A comparison of real-time PCR and reverse line blot hybridization in detecting feline haemoplasmas of domestic cats and an analysis of risk factors associated with haemoplasma infections. Veterinary Research 8:103.

Korman R, Cerón JJ, Knowles TG, Barker EN, Eckersall PD & Tasker S. (2012). Acute phase response to Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ infection in FIV-infected and non FIV-infected cats. The Veterinary Journal 193: 433-438. Barker E.N., Darby A.C., Helps C.R., Peters I.R., Heesom K.J., Arthur C.J., Crossett B., Radford A.D. and Tasker S. (2011). Molecular characterization of the haemotrophic bacterium Mycoplasma haemofelis. Veterinary Research. 42, 1-8.

Steer JA & Tasker S, Barker EN, Jensen J, Mitchell J, Stocki T, Chalker VJ & Hamon M. (2011). A Novel Hemotropic Mycoplasma (Hemoplasma) in a Patient with Hemolytic Anemia and Pyrexia' Clinical Infectious Diseases 53: 147-151.

Barker E.N., Helps C.R., Neimark H., Peters I.R., Peters W. and Tasker S. (2011). A novel haemoplasma species identified in archived primate blood smears. Vet. Microbiol. 149, 478-481.

Barker E.N., Helps C.R., Peters I.R., Darby A.C., Radford A.D. and Tasker S. (2011). Complete Genome Sequence of Mycoplasma haemofelis, a Hemotropic Mycoplasma. Journal of Bacteriology. 193, 2060-2061.

Maher I., Tasker S., Helps C.R. and Papasouliotis K. (2010). PCR survey of haemoplasmas in cats living in Greece. Journal of Feline Medicine and Surgery. 12, 601-605.

Tasker S., Peters I.R., Papasoulotis K., Cue S.M., Willi B., Hofmann-Lehmann R., Gruffydd-Jones T.J., Knowles T.G., Day M.J. and Helps C.R. (2009). Description of outcomes of experimental infection with feline haemoplasmas: copy numbers, haematology, Coombs' testing and blood glucose concentrations. Vet. Micro. 139, 323-332.

Peters I.R., Helps C.R., McAuliffe L., Neimark H., Lappin M.R., Gruffydd-Jones T.J., Day M.J., Hoelzle L.E., Willi B., Meli M., Hofmann-Lehmann R. and Tasker S. (2008). RNaseP RNA gene (rnpB) phylogeny of Haemoplasmas and other Mycoplasma species. J. Clin. Micro. 46, 1873-1877.

Dean R., Helps C.R., Gruffydd-Jones T.J. and Tasker S. (2008). Use of real-time PCR to detect Mycoplasma haemofelis & ‘Candidatus Mycoplasma haemominutum’ in the saliva and salivary glands of haemoplasma-infected cats. Journal of Feline Medicine and Surgery. 10, 413-417.

Peters I.R., Helps C.R., Willi B., Hofmann-Lehmann R. and Tasker S. (2007). The prevalence of three species of feline haemoplasmas in samples submitted to a diagnostic service as determined by three novel real-time duplex PCR assays. Veterinary Microbiology. 126, 142-150.

Tasker S. (2006) Current concepts in feline haemobartonellosis. In Practice. 28, 136-141.

Tasker S, Caney S.M.A., Day M.J., Dean R.J., Helps C.R., Knowles T.G., Lait P.J.P., Pinches M.D.G. and Gruffydd-Jones T.J. (2006). Effect of chronic FIV infection, and efficacy of marbofloxacin treatment, on Mycoplasma haemofelis infection. Veterinary Microbiology. 117, 169-179.

Tasker S, Caney S.M.A., Day M.J., Dean R.J., Helps C.R., Knowles T.G., Lait P.J.P., Pinches M.D.G. and Gruffydd-Jones T.J. (2006). Effect of chronic feline immunodeficiency virus infection, and efficacy of marbofloxacin treatment, on 'Candidatus Mycoplasma haemominutum' infection. Microbes and Infection. 8, 653-661.

Willi B, Tasker S, Boretti F.S, Doherr M.D, Cattori V, Meli M L, Lobetti R.G. Malik R. Reusch C.E, Lutz H and Hofmann-Lehmann R. (2006) Phylogenetic analysis of ‘Candidatus Mycoplasma turicensis’ isolates from pet cats in the UK, Australia and South Africa, with analysis of risk factors for infection. Journal of Clinical Microbiology. 44(12), 4430-4435.

Gary AT, Richmond HL, Tasker S, Hackett TB and Lappin MR. (2006) Survival of Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ in blood of cats used for transfusions. Journal of Feline Medicine and Surgery. 8, 321-326.

Willi B, Boretti FS, Baumgartner C, Tasker S, Wenger B, Cattori V, Meli ML, Reusch C, Lutz H and Hofmann-Lehmann RH. (2006) Prevalence, risk factor analysis and follow up of infections with the three feline haemoplasma species in cats in Switzerland. Journal of Clinical Microbiology. 44, 961-969.

Willi B, Boretti FS, Cattori V, Tasker S, Meli ML, Reusch C, Lutz H and Hofmann-Lehmann RH. (2005) Identification, molecular characterization and experimental transmission of a new hemoplasma isolate from a cat with hemolytic anemia in Switzerland. Journal of Clinical Microbiology. 43, 2581-2585.

Tasker S., Braddock J.A., Baral R., Helps C.R., Day M.J., Gruffydd-Jones T.J. and Malik R. (2004). Diagnosis of Feline Haemoplasma infection in Australian cats using a real-time PCR assay. Journal of Feline Medicine and Surgery. 6, 345-354.

Kenny MJ, Shaw SE, Beugnet F and Tasker S. (2004) Demonstration of Two Distinct Haemotropic Mycoplasmas in French Dogs. Journal of Clinical Microbiology. 42, 5397-5399.

Lobetti RG and Tasker S. (2004) Diagnosis of feline haemoplasma infection using a real-time PCR assay. Journal of the South African Veterinary Association. 75, 94-99.

Braddock JA, Tasker S and Malik R. (2004) The Use of PCR in the Diagnosis and Monitoring of Mycoplasma haemofelis copy number in a naturally-infected cat. Journal of Feline Medicine and Surgery. 6, 161-165.

Tasker S., Helps C.R., Day M.J., Harbour D.A., Gruffydd-Jones T.J. and Lappin M.R. (2004). Use of a Taqman PCR to Determine the Response of Mycoplasma haemofelis Infection to Antibiotic Treatment. Journal of Microbiological Methods 56, 63-71.

Tasker S., Helps C.R., Day M.J., Harbour D.A., Shaw S.E., Harrus S., Baneth G., Lobetti R.G., Malik R., Beaufils J.P., Belford C.R. and Gruffydd-Jones T.J. (2003). Phylogenetic analysis of haemoplasma species - an international study. Journal of Clinical Microbiology. 41, 3877-3880.

Tasker S., Binns S. H., Day M. J., Gruffydd-Jones T. J., Harbour D. A., Helps C. R., Jensen W. A., Olver C. S. and Lappin M. R. (2003). Use of a polymerase chain reaction assay to assess prevalence of 'Candidatus Mycoplasma haemofelis' and 'Candidatus Mycoplasma haemominutum' in Great Britain and assessment of risk factors for infection. Veterinary Record. 152, 193-198.

Tasker S., Helps C. R., Day M. J., Gruffydd-Jones T. J. and Harbour D. A. (2003). Use of Real-Time PCR to detect and quantify Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ infection. Journal of Clinical Microbiology. 41, 439-441.

Tasker S and Lappin MR. (2002) Haemobartonella felis: recent developments in diagnosis and treatment. Journal of Feline Medicine and Surgery. 4, 3-11.

Tasker S., Helps C. R., Belford C. J., Birtles R. J., Day M. J., Sparkes A. H., Gruffydd-Jones T. J. and Harbour D. A. (2001). 16S rDNA comparison demonstrates near identity between an United Kingdom Haemobartonella felis strain and the American California strain. Veterinary Microbiology. 81, 73-78.

Feline Herpesvirus

Schulz C., Hartmann K., Mueller R.S., Helps C.R. and Schulz B.S. (2015). Sampling sites for detection of feline herpesvirus-1, feline calicivirus and Chlamydia felis in cats with feline upper respiratory tract disease. Journal of Feline Medicine and Surgery. 17, 1012-1019.

Friedl Y., Schulz B., Knebl A., Helps C.R., Truyen U. and Hartmann K. (2014). Efficacy of passively transferred antibodies in cats with acute viral upper respiratory tract infection. Veterinary Journal. 201, 316-321.

Ballin A.C., Schulz B., Helps C.R., Sauter-Louis C., Mueller R.S. and Hartmann K. (2014). Limited efficacy of topical recombinant feline interferon-omega for treatment of cats with acute upper respiratory viral disease. The Veterinary Journal. 202, 466-470.

Segarra S., Papasouliotis K. and Helps C.R. (2011). The in vitro effects of proxymetacaine, fluorescein and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Veterinary Ophthalmology. 14, 5-8.

Helps C.R., Lait P., Damhuis A., Björnehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G., Fontbonne A., Grazia Pennisi M., Gruffydd-Jones T., Gunn-Moore D., Hartmann K., Lutz H., Malandain E., Möstl K., Stengel C., Harbour D.A. and Graat E.A.M. (2005). Factors associated with upper respiratory tract disease caused by FHV, FCV, C. felis and B. bronchiseptica in cats - experience from 218 European catteries. The Veterinary Record. 156, 669-673.

Helps C.R., Reeves N. A., Egan K., Howard P. and Harbour D.A. (2003). Detection of Chlamydophila felis and feline herpesvirus by multiplex real-time PCR. Journal of Clinical Microbiology. 41, 2734-2736.

Feline Immunodeficiency Virus

Pinches M.D.G., Diesel G., Helps C.R., Tasker S., Egan K. and Gruffydd-Jones T.J. (2006). An update on in practice FIV and FeLV screening test performance using a bayesian statistical approach. Veterinary Clinical Pathology. 36, 141-147.

Feline Leukaemia Virus

Sparkes AH, Tasker S, Thibault JC & Poulet H. (2015). A comparative study of the efficacy of a canarypox based recombinant leukaemia vaccine against a natural contact FeLV challenge in cats. Journal of Vaccines & Vaccination 6 6.

Pinches M.D.G., Helps C.R., Gruffydd-Jones T.J., Egan K., Jarrett O. and Tasker S. (2006). Diagnosis of feline leukaemia virus infection by quantitative real-time polymerase chain reaction. Journal of Feline Medicine and Surgery. 9, 8-13.

Pinches M.D.G., Diesel G., Helps C.R., Tasker S., Egan K. and Gruffydd-Jones T.J. (2006). An update on in practice FIV and FeLV screening test performance using a bayesian statistical approach. Veterinary Clinical Pathology. 36, 141-147.

Genetic Diseases and Traits

Burmese Head Defect

Lyons L.A., Erdman C.A., Grahn R.A., Hamilton M.J., Carter M., Helps C.R., Alhaddad H. and Gandolfi B. (2016). Aristaless-like homeobox protein 1 (ALX1) variant associated with craniofacial structure and frontonasal dysplasia in Burmese cats. Developmental Biology. 15;409 451-458.

Burmese Hypokalaemia

Malik R., Musca F., Gunew M., Menrath V., Simpson C., Culvenor J., Grahn R., Helps C.R., Lyons L.A. and Gandolfi B. (2015). Periodic hypokalaemic polymyopathy in Burmese and closely related cats. Journal of Feline Medicine and Surgery. 17, 417-426.

Gandolfi B., Gruffydd-Jones T.J., Malik R., Cortes A., Jones B.R., Helps C.R., Prinzenberg E.M., Erhardt G. and Lyons L.A. (2012). First WNK4 - Hypokalemia Animal Model Identified by Genome-wide Association in Burmese Cats. PLoS ONE. 7(12): e53173.

Feline Coat Colour Genetics

Gershony L.C., Penedo M.C., Davis B.W., Murphy W.J., Helps C.R. and Lyons L.A. (2014). Who’s behind that mask and cape? The Asian leopard cat’s Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. Animal Genetics. 45, 893-897.

Feline Genetic Blood Typing

Gandolfi B., Grahn R.A., Gustafson N., Proverbio D., Spada E., Adhikari B., Cheng J., Andrews G., Lyons L.A. and Helps C.R. (2016). A novel variant in CMAH is associated with blood type AB in Ragdoll cats. PLoS ONE. 12;11(5):e0154973.

Tasker S., Barker E.N., Day M.J. and Helps C.R. (2014). Feline blood genotyping versus phenotyping, and detection of non-AB blood type incompatibilities in UK cats. Journal of Small Animal Practice. 55, 185-189.

Feline Polycystic Kidney Disease

Wills S.J., Barrett E.L, Barr F.J., Bradley K.J., Helps C.R., Cannon M.J. and Gruffydd-Jones T.J. (2009). Evaluation of the repeatability of ultrasound scanning for the detection of feline polycystic kidney disease. Journal of Feline Medicine and Surgery. 11(12), 993-996.

Helps C.R., Tasker S., Barr F.J., Wills S.J. and Gruffydd-Jones T.J. (2007). Detection of the single nucleotide polymorphism causing feline autosomal-dominant polycystic kidney disease in Persians from the UK using a novel real-time PCR assay. Molecular and Cellular Probes. 21, 31-34.

Helps C.R., Tasker, S. and Harley R. (2007). Correlation of the feline PKD 1 genetic mutation with cases of PKD diagnosed by pathological examination. Experimental and Molecular Pathology. 83, 264-268.

Feline Pyruvate Kinase Deficiency

Grahn R.A., Grahn J.C., Penedo M.C.T., Helps C.R. and Lyons L.A. (2012). Erythrocyte Pyruvate Kinase Deficiency Mutation Identified in Multiple Breeds of Domestic Cats. BMC Vet Res. 8, 207.

Hypertrophic Cardiomyopathy

Casamian-Sorrosal D., Chong S.K., Fonfara S. and Helps C.R. (2014). Prevalence and demographics of the MYBPC3 mutations in Ragdolls and Maine Coons in the British Isles. Journal of Small Animal Practice. 55, 269-273.

Borgeat K., Casamian-Sorrosal D., Helps C.R., Fuentes V.L. and Connolly D.J. (2014). Association of the myosin binding protein C3 mutation (MYBPC3 R820W) with cardiac death in a survey of 236 Ragdoll cats. Journal of Veterinary Cardiology. 16, 73-80.

Persian Progressive Retinal Atrophy

Lyons L.A., Creighton E.K., Alhaddad H., Beale H.C., Grahn R.A., Rah H., Maggs D.J., Helps C.R. and Gandolfi B. (2016). Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7. BMC Genomics. 17, 265.

Acarus Laboratory

Tick Borne Diseases

Abdullah S, Helps C, Tasker S, Newbury H & Wall R. (2016). Ticks infesting domestic dogs in the UK: a large-scale surveillance programme. Parasites and Vectors 9 391.

Crawford K, Walton J, Lewis D, Tasker S & Warman SM. (2013). Infectious agent screening in canine blood donors in the United Kingdom. Journal of Small Animal Practice 54: 414-417.

Falkenö O, Tasker S, Osterman-Lind E & Tvedten HW. (2013). Theileria annae in a young Swedish dog. Acta Veterinaria Scandinavica 55: 50.

Tasker S. (2013). Exotic diseases; a growing concern? Journal of Small Animal Practice 54: 393-394.

Jefferies R, Shaw SE, Willesen J, Viney ME, Morgan ER. Elucidating the spread  of the emerging canid nematode Angiostrongylus vasorum between Palaearctic and Nearctic ecozones. Infect Genet Evol. 2010 Feb 6.

Jefferies R, Morgan ER, Shaw SE. A SYBR green real-time PCR assay for the detection of the nematode Angiostrongylus vasorum in definitive and intermediate hosts. Vet Parasitol. 2009 Dec 3;166(1-2):112-8.

Morgan ER, Jefferies R, Krajewski M, Ward P, Shaw SE. Canine pulmonary angiostrongylosis: the influence of climate on parasite distribution. Parasitol Int. 2009 Dec;58(4):406-10.

Shaw SE, Langton DA, Hillman TJ. Canine leishmaniosis in the United Kingdom: a zoonotic disease waiting for a vector? Vet Parasitol. 2009 Aug 26;163(4):281-5

Marié JL, Shaw SE, Langton DA, Bourry O, Gomez J, Davoust B. Sub-clinical infection of dogs from the Ivory Coast and Gabon with Ehrlichia, Anaplasma, Mycoplasma and Rickettsia species. Clin Microbiol Infect. 2009 May 18.

Robinson MT, Hillman T, Langton DA, Shaw SE. Bartonella clarridgeiae in a cat in the UK. Vet Rec. 2009 Jan 10;164(2):58-9.

Jefferies R, Shaw SE, Viney ME, Morgan ER. Angiostrongylus vasorum from South America and Europe represent distinct lineages. Parasitology. 2009 Jan;136(1):107-15.

Shaw SE, Hillman T, Wray J. Unusual case of Canine leishmaniosis in the UK.Vet Rec. 2008 Aug 30;163(9):283.

Shaw SE, Langton DA, Hillman TJ. Canine leishmaniosis in the UK. Vet Rec. 2008 Aug 23;163(8):253-

Hawley JR, Shaw SE, Lappin MR. Prevalence of Rickettsia felis DNA in the blood of cats and their fleas in the United States.J Feline Med Surg. 2007 Jun;9(3):258-62.

Yamasaki M, Inokuma H, Sugimoto C, Shaw SE, Aktas M, Yabsley MJ, Yamato O, Maede Y. Comparison and phylogenetic analysis of the heat shock protein 70 gene of Babesia parasites from dogs. Vet Parasitol. 2007 Apr 30;145(3-4):217-27.

Holm LP, Kerr MG, Trees AJ, McGarry JW, Munro ER, Shaw SE. Fatal babesiosis in an untravelled British dog. Vet Rec. 2006 Aug 5;159(6):179-80

Bauer O, Baneth G, Eshkol T, Shaw SE, Harrus S. Polygenic detection of Rickettsia felis in cat fleas (Ctenocephalides felis) from Israel. Am J Trop Med Hyg. 2006 Mar;74(3):444-8.

Shaw SE, Binns SH, Birtles RJ, Day MJ, Smithson R, Kenny MJ. Molecular evidence of tick-transmitted infections in dogs and cats in the United Kingdom. Vet Rec. 2005 Nov 19;157(21):645-8.

Morgan ER, Shaw SE, Brennan SF, De Waal TD, Jones BR, Mulcahy G. Angiostrongylus vasorum: a real heartbreaker. Trends Parasitol. 2005 Feb;21(2):49-51. Review.

Kenny MJ, Shaw SE, Beugnet F, Tasker S. Demonstration of two distinct hemotropic mycoplasmas in French dogs. J Clin Microbiol. 2004 Nov;42(11):5397-9.

Shaw SE, Kenny MJ, Tasker S, Birtles RJ. Pathogen carriage by the cat flea Ctenocephalides felis (Bouché) in the United Kingdom.Vet Microbiol. 2004 Sep 8;102(3-4):183-8.

Kenny MJ, Shaw SE, Hillyard PD, Forbes AB. Ectoparasite and haemoparasite risks associated with imported exotic reptiles. Vet Rec. 2004 Apr 3;154(14):434-5.

Baneth G, Kenny MJ, Tasker S, Anug Y, Shkap V, Levy A, Shaw SE. Infection with a proposed new subspecies of Babesia canis, Babesia canis subsp. presentii, in domestic cats. J Clin Microbiol. 2004 Jan;42(1):99-105.

Kenny MJ, Birtles RJ, Day MJ, Shaw SE. Rickettsia felis in the United Kingdom.Emerg Infect Dis. 2003 Aug;9(8):1023-4

Shaw SE. [Interview with Susan E. Shaw at Chateau Veterinair. Dangers of traveling with pets through Europe. Interview by F. J. W. C. van Herten].Tijdschr Diergeneeskd. 2003 Apr 15;128(8):251-3.

Shaw SE, Lerga AI, Williams S, Beugnet F, Birtles RJ, Day MJ, Kenny MJ. Review of exotic infectious diseases in small animals entering the United Kingdom from abroad diagnosed by PCR. Vet Rec. 2003 Feb 8;152(6):176-7.

Birtles RJ, Laycock G, Kenny MJ, Shaw SE, Day MJ. Prevalence of Bartonella species causing bacteraemia in domesticated and companion animals in the United Kingdom. Vet Rec. 2002 Aug 24;151(8):225-9.

Baneth G, Shaw SE. Chemotherapy of Canine leishmaniosis. Vet Parasitol. 2002 Jul 2;106(4):315-24. Review.

Shaw SE, Birtles RJ, Day MJ.Arthropod-transmitted infectious diseases of cats. J Feline Med Surg. 2001 Dec;3(4):193-209. Review.

Shaw SE, Day MJ, Birtles RJ, Breitschwerdt EB. Tick-borne infectious diseases of dogs. Trends Parasitol. 2001 Feb;17(2):74-80. Review.

Wall R, Shaw SE, Penaliggon J. The prevalence of flea species on cats and dogs in Ireland. Med Vet Entomol. 1997 Oct;11(4):404-6

Meat Spoilage

Clostridium estertheticum

Cavill L., Renteria-Monterrubio A.L., Helps C.R. and Corry J.E.L. (2011). Detection of cold-tolerant clostridia other than Clostridium estertheticum in raw vacuum-packed chill-stored meat. Food Microbiology. 28, 957-963.

Helps C. R., Harbour D. A. and Corry J. E. (1999). PCR-based 16S ribosomal DNA detection technique for Clostridium estertheticum causing spoilage in vacuum-packed chill-stored beef. International Journal of Food Microbiology. 52, 57-65.